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Binding to such antibodies would neutralize streptokinase molecules. With alteplase, another endogenous plasminogen activator (tissue plasminogen activator, tPA) is available. With physiological concentrations this activator preferentially acts on plasminogen bound to fibrin.
His idea was this: when given in normal (allopathic) dosage, a drug (in the sense of medicament) will produce a constellation of symptoms; however, in a patient whose disease symptoms resemble just this mosaic of symptoms, the same drug (simile principle) would effect a cure when given in a very low dosage (“potentiation”). |
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