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Therefore, receptor binding must not be implied until it can be shown that binding is saturable (saturability); the only substances bound are those possessing the same pharmacological mechanism of action (specificity); binding affinity of different substances is correlated with their pharmacological potency.
Relevant parameters include: antipsychotic efficacy (symbolized by the arrow); the extent of sedation; and the ability to induce extrapyramidal adverse effects. The latter depends on relative differences in antagonism towards dopamine and acetylcholine, respectively.

 

Only when monotherapy with different agents proves inadequate can changeover to a second-line drug or combined use (“add on”) be recommended (B), provided that the possible risk of pharmacokinetic interactions is taken into account (see below). The precise mode of action of antiepileptic drugs remains unknown. Some agents appear to lower neuronal excitability by several mechanisms of action.
To forestall depletion of NaCl and water, the body responds with an increased release of aldosterone, which stimulates their reabsorption in the kidney. The action of aldosterone is, however, associated with increased renal excretion of KCl. The enteral and renal K+ loss add up to a K+ depletion of the body, evidenced by a fall in serum K+ concentration (hypokalemia).

 

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