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As “slow-reacting substances of anaphylaxis,” they are involved in allergic reactions; together with PG, they evoke the spectrum of characteristic inflammatory symptoms: redness, heat, swelling, and pain. Therapeutic applications. PG derivatives are used to induce labor or to interrupt gestation (p. 126); in the therapy of peptic ulcer, and in peripheral arterial disease.
In Phase II (synthetic) reactions, conjugation products of either the drug itself or its Phase I metabolites are formed, for instance, with glucuronic or sulfuric acid. The special case of the endogenous transmitter acetylcholine illustrates well the high velocity of ester hydrolysis.

 

When amphetamine-like substances are misused to enhance athletic performance (doping), there is a risk of dangerous physical overexertion. Because of the absence of a sense of fatigue, a drugged athlete may be able to mobilize ultimate energy reserves. In extreme situations, cardiovascular failure may result (B).
Body weight may be broken down as follows: Further subdivisions are shown in the table. The volume ratio interstitial: intracellular water varies with age and body weight. On a percentage basis, interstitial fluid volume is large in premature or normal neonates (up to 50 % of body water), and smaller in the obese and the aged.

 

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