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The concentration at which a maximal effect occurs cannot be measured accurately; however, that eliciting a half-maximal effect (EC50) is readily determined. It typically corresponds to the inflection point of the concentration– response curve in a semilogarithmic plot (log concentration on abscissa).
The effect reflects an enhanced readiness to perceive external stimuli (attentiveness) and to respond to them. The multiplicity of its effects makes nicotine ill-suited for therapeutic use. The dried and cured leaves of the nightshade plant Nicotiana tabacum are known as tobacco. Tobacco is mostly smoked, less frequently chewed or taken as dry snuff.

 

From ampules for multiple or single use, the solution is aspirated via a needle into a syringe. The cartridge ampule is fitted into a special injector that enables its contents to be emptied via a needle. An infusion refers to a solution being administered over an extended period of time. Solutions for infusion must meet the same standards as solutions for injection.
The hydroxyl groups of catecholamines are responsible for the very low lipophilicity of these substances. Polarity is increased at physiological pH due to protonation of the amino group. Deletion of one or all hydroxyl groups improves membrane penetrability at the intestinal mucosa-blood and the bloodbrain barriers.

 

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