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In general, subjects complain of increased nervousness, lack of concentration, and weight gain. Dopamine A. As the precursor of norepinephrine and epinephrine, dopamine is found in sympathetic (adrenergic) neurons and adrenomedullary cells. In the CNS, dopamine itself serves as a neuromediator and is implicated in neostriatal motor programming.
Sympathetic activation gives rise to an increase in heart rate and systolic muscle tension, enabling cardiac output to be restored to a level comparable to that in a healthy subject. When sympathetic drive is eliminated during ?-receptor blockade, stroke volume and cardiac rate decline, a latent myocardial insufficiency is unmasked, and overt insufficiency is exacerbated (A). |
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