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M-cholinoceptors can be classified into subtypes according to their molecular structure, signal transduction, and ligand affinity. Here, the M1, M2, and M3 subtypes are considered. M1 receptors are present on nerve cells, e.g., in ganglia, where they mediate a facilitation of impulse transmission from preganglionic axon terminals to ganglion cells.
Benzene, polycyclic aromatic compounds (e. g. , benzopyrene), and unsaturated cyclic carbohydrates can be converted by mono-oxygenases to epoxides, highly reactive electrophiles that are hepatotoxic and possibly carcinogenic. The second type of oxidative biotransformation comprises dealkylations.

 

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