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For that reason, the oral route (i.e., simple application by mouth) involving subsequent uptake of drug across the gastrointestinal mucosa into the blood is chosen much more frequently. The disadvantage of this route is that the drug must pass through the liver on its way into the general circulation.
It is stored instead of NE, but is unable to mimic the functions of the latter. In addition, it stabilizes the axonal membrane, thereby impeding the propagation of impulses into the sympathetic nerve terminals. Storage and release of epinephrine from the adrenal medulla are not affected, owing to the absence of a re-uptake process. |
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