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The point of contact (synapse) between the first and second neurons occurs mainly in ganglia; therefore, the first neuron is referred to as preganglionic and efferents of the second as postganglionic. Electrical excitation (action potential) of the first neuron causes the release of acetylcholine (ACh) within the ganglia.
Because histamine plays a pivotal role in the activation of parietal cells, H2-antihistamines also diminish responsivity to other stimulants, e. g. , gastrin (in gas-trin-producing pancreatic tumors, Zollinger- Ellison syndrome).

 

Frequently there is memory loss for the duration of the recovery period; however, adults in particular complain about distressing dream-like experiences. These can be counteracted by administration of a benzodiazepine (e. g. , midazolam).
Alternate-day therapy: Twice the daily dose is given on alternate mornings. On the “off” day, endogenous cortisol production is allowed to occur. The disadvantage of either regimen is a recrudescence of disease symptoms during the glucocorticoid-free interval. Androgens are masculinizing substances.

 

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