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They act on uterine and vascular muscle. Ergometrine particularly stimulates the uterus. It readily induces a tonic contraction of the myometrium (tetanus uteri). This jeopardizes placental blood flow and fetal O2 supply. The semisynthetic derivative methylergometrine is therefore used only after delivery for uterine contractions that are too weak.
They act on the luminal membrane of the tubule cells. Loop diuretics have the highest efficacy. Thiazides are most frequently used. Their forerunners, the carbonic anhydrase inhibitors, are now restricted to special indications. Carbonic anhydrase (CAH) inhibitors, such as acetazolamide and sulthiame, act predominantly in the proximal tubules.

 

Indications: prophylaxis of hay fever, allergic asthma, and food allergies. 2. Blockade of histamine receptors. Allergic reactions are predominantly mediated by H1 receptors. H1 antihistamines are mostly used orally. Their therapeutic effect is often disappointing. Indications: allergic rhinitis (hay fever).
The “early” endosome delivers its contents to predetermined destinations, e.g., the Golgi complex, the cell nucleus, lysosomes, or the opposite cell membrane (transcytosis). Unlike simple endocytosis, receptor-mediated endocytosis is contingent on affinity for specific receptors and operates independently of concentration gradients.

 

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