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N-reductions occur in azo- or nitro-compounds (e. g. , nitrazepam). Nitro groups can be reduced to amine groups via nitroso and hydroxylamino intermediates. Likewise, dehalogenation is a reductive process involving a carbon atom (e. g. , halothane, p. 218).
Administration of a placebo may elicit the desired effect (relief of symptoms) or undesired effects that reflect a change in the patient’s psychological situation brought about by the therapeutic setting.

 

Therapeutically used Ca2+ antagonists can be divided into three groups according to their effects on heart and vasculature. I.Dihydropyridine derivatives. The dihydropyridines, e.g., nifedipine, are uncharged hydrophobic substances. They induce a relaxation of vascular smooth muscle in arterial beds. An effect on cardiac function is practically absent at therapeutic dosage.
They occur in the leaves (folia sennae) or fruits (fructus sennae) of the senna plant, the bark of Rhamnus frangulae and Rh. purshiana, (cortex frangulae, cascara sagrada), the roots of rhubarb (rhizoma rhei), or the leaf extract from Aloe species (p. 176). The structural features of anthraquinone derivatives are illustrated by the prototype structure depicted.

 

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