Drug Name Tetracycline

This structural element is unimportant for efficacy; even drugs containing a methylene bridge, such as chlorpromazine (p. 236) or imipramine (p. 230), would exert a local anesthetic effect with appropriate application. Ester-type local anesthetics are subject to inactivation by tissue esterases. This is advantageous because of the diminished danger of systemic intoxication.
Dopamine agonist-induced nausea in parkinsonian patients can be counteracted with D2-receptor antagonists that penetrate poorly into the CNS (e. g. , domperidone, sulpiride).

 

The ergolides, bromocriptine, pergolide, and lisuride, are ligands at Dreceptors whose therapeutic effects are probably due to stimulation of D2 receptors (indications: parkinsonism, suppression of lactation, infertility, acromegaly. Typical adverse effects of these substances are nausea and vomiting. As indirect dopamine-mimetics, (+)- amphetamine and ritaline augment dopamine release.
d-Tubocurarine is given by i. v. injection (average dose approx. 10 mg). It binds to the endplate nicotinic cholinoceptors without exciting them, acting as a competitive antagonist towards ACh. By preventing the binding of released ACh, it blocks neuromuscular transmission. Muscular paralysis develops within about 4 min. d-Tubocurarine does not penetrate into the CNS.