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As for the calcium antagonists, it should be noted that verapamil, unlike nifedipine, possesses cardiodepressant activity. ?-Blockers may be of particular benefit in patients with benign prostatic hyperplasia and impaired micturition.
The van der Waals’ bond, therefore, is a form of electrostatic attraction, albeit of very low strength (inversely proportional to the seventh power of the distance). Hydrophobic interaction (C). The attraction between the dipoles of water is strong enough to hinder intercalation of any apolar (uncharged) molecules.

 

The initiation of an epileptic attack involves “pacemaker” cells; these differ from other nerve cells in their unstable resting membrane potential, i. e. , a depolarizing membrane current persists after the action potential terminates. Therapeutic interventions aim to stabilize neuronal resting potential and, hence, to lower excitability.
The effectiveness of such indirect sympathomimetics diminishes or disappears (tachyphylaxis) when vesicular stores of NE close to the axolemma are depleted. Indirect sympathomimetics can penetrate the blood-brain barrier and evoke such CNS effects as a feeling of well-being, enhanced physical activity and mood (euphoria), and decreased sense of hunger or fatigue.

 

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