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Benzodiazepines are the drugs of choice for status epilepticus (see above); however, development of tolerance renders them less suitable for long-term therapy. Clonazepam is used for myoclonic and atonic seizures. Clobazam, a 1,5-benzodiazepine exhibiting an increased anticonvulsant/sedative activity ratio, has a similar range of clinical uses.
The chemically simple molecule is now produced synthetically. Erythromycin suppresses advancement of the ribosome. Its action is predominantly bacteriostatic and directed against gram-positve organisms. For oral administration, the acid-labile base (E) is dispensed as a salt (E. stearate) or an ester (e. g. , E. succinate). Erythromycin is well tolerated.

 

In ATP-depleted cells in the infarct border zone, resting membrane potential declines with a concomitant increase in excitability that may be further exacerbated by activation of ?-adrenoceptors. Together, both processes promote the risk of fatal ventricular arrhythmias.
Prednisone is a glucocorticoid prodrug that is converted by 11beta-hydroxysteroid dehydrogenase in the liver into the active form, prednisolone.[1] It is used to treat certain inflammatory diseases (such as moderate allergic reactions) and (at higher doses) some types of cancer, but has many significant adverse effects.

 

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