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During initial contact with the drug, the immune system is sensitized: antigen-specific lymphocytes of the T-type and B-type (antibody formation) proliferate in lymphatic tissue and some of them remain as socalled memory cells. Usually, these processes remain clinically silent. During the second contact, antibodies are already present and memory cells proliferate rapidly.
The proteins are used as “viral enzymes” catalyzing viral multiplication (e. g. , DNA polymerase and thymidine kinase), as capsomers, or as coat components, or are incorporated into the host cell membrane. (5) Individual components are assembled into new virus particles (maturation). (6) Release of daughter viruses results in spread of virus inside and outside the organism. |
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