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Since they can damage epiphyseal chondrocytes and joint cartilages in laboratory animals, gyrase inhibitors should not be used during pregnancy, lactation, and periods of growth. Azomycin (nitroimidazole) derivatives, such as metronidazole, damage DNA by complex formation or strand breakage. This occurs in obligate anaerobes, i. e. , bacteria growing under O2 exclusion.
Binding to such antibodies would neutralize streptokinase molecules. With alteplase, another endogenous plasminogen activator (tissue plasminogen activator, tPA) is available. With physiological concentrations this activator preferentially acts on plasminogen bound to fibrin.

 

Unlike inhalational agents, most of these drugs affect consciousness only and are devoid of analgesic activity (exception: ketamine). The effect cannot be ascribed to nonselective binding to neuronal cell membranes, although this may hold for propofol. Most injectable anesthetics are characterized by a short duration of action.
Preparations for oral use are derivatives of 17?- ethinyltestosterone = ethisterone (e. g. , norethisterone, dimethisterone, lynestrenol, desogestrel, gestoden), or of 17?-hydroxyprogesterone acetate (e. g. , chlormadinone acetate or cyproterone acetate). These agents are mainly used as the progestin component in oral contraceptives.

 

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