Drug Name Lotensin

The topically active allylamine naftidine and the morpholine amorolfine also inhibit ergosterol synthesis, albeit at another step. The polyene antibiotics, amphotericin B and nystatin, are of bacterial origin. They insert themselves into fungal cell membranes (probably next to ergosterol molecules) and cause formation of hydrophilic channels.
Change in site of action: e. g. , increased synthesis of dihydrofolate reductase may occur as a compensatory response to methotrexate. Damage repair: DNA repair enzymes may become more efficient in repairing defects caused by cisplatin. Both the prevention of transplant rejection and the treatment of autoimmune disorders call for a suppression of immune responses.

 

The antihypertensive agents, reserpine (obsolete) and ?-methyldopa, deplete neuronal stores of the amine. A common adverse effect of dopamine antagonists or depletors is parkinsonism. Histamine (B).Histamine is stored in basophils and tissue mast cells.
Anti-inflammatory therapy is the more successful the less use is made of asneeded ?2-mimetic medication. Severe cases may, however, require an intensified bronchodilator treatment with systemic ?2-mimetics or theophylline (systemic use only; low therapeutic index; monitoring of plasma levels needed).