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Administration of levodopa plus carbidopa (or benserazide) remains the most effective treatment, but does not provide benefit beyond 3–5 y and is followed by gradual loss of symptom control, on-off fluctuations, and development of orobuccofacial and limb dyskinesias. These long-term drawbacks of levodopa therapy may be delayed by early monotherapy with dopamine receptor agonists.
At dosages below those needed to treat malignancies, some cytostatics are also employed for immunosuppression, e. g. , azathioprine, methotrexate, and cyclophosphamide. The antiproliferative effect is not specific for lymphocytes and involves both T- and Bcells. Mycophenolate mofetil has a more specific effect on lymphocytes than on other cells. |
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