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Administration of levodopa plus carbidopa (or benserazide) remains the most effective treatment, but does not provide benefit beyond 3–5 y and is followed by gradual loss of symptom control, on-off fluctuations, and development of orobuccofacial and limb dyskinesias. These long-term drawbacks of levodopa therapy may be delayed by early monotherapy with dopamine receptor agonists.
A carrier mechanism moves Na+ across the membrane. Energy liberated during this influx can be utilized for the coupled outward transport of another particle against a gradient. From the cell interior, Na+ is moved with expenditure of energy (ATP hydrolysis) by Na+/K+-ATPase into the extracellular space.

 

At dosages below those needed to treat malignancies, some cytostatics are also employed for immunosuppression, e. g. , azathioprine, methotrexate, and cyclophosphamide. The antiproliferative effect is not specific for lymphocytes and involves both T- and Bcells. Mycophenolate mofetil has a more specific effect on lymphocytes than on other cells.
Functional antagonists of mediators of allergy. a) ?-Sympathomimetics, such as naphazoline, oxymetazoline, and tetrahydrozoline, are applied topically to the conjunctival and nasal mucosa to produce local vasoconstriction, and decongestion and to dry up secretions, e. g. , in hay fever.

 

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