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linical studies In vivo studies have been performed on oral fast-disintegrating dosage forms to investigate their behavior in the oral–esophageal tract, their pharmacokinetic and therapeutic efficacy, and acceptability. Zydis’s residence time in the mouth and stomach, and its transit through the esophageal tract, was investigated using gamma-scintigraphy.
There are several vitamin K derivatives of different origins: K1 (phytomenadione) from chlorophyllous plants; K2 from gut bacteria; and K3 (menadione) synthesized chemically. All are hydrophobic and require bile acids for absorption. |
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