Drug Name Medrol

Increased sensitivity of the respiratory center to morphine is found in patients with chronic lung disease, in neonates, or during concurrent exposure to other respiratory depressant agents. The DRC is shifted to the left and a smaller dose of morphine is sufficient to paralyze respiration. Genetic anomalies of metabolism may also lead to hypersensitivity.
Type 2, cytotoxic reaction. Drugantibody (IgG) complexes adhere to the surface of blood cells, where either circulating drug molecules or complexes already formed in blood accumulate. These complexes mediate the activation of complement, a family of proteins that circulate in the blood in an inactive form, but can be activated in a cascadelike succession by an appropriate stimulus.

 

In terms of their positive inotropic effect, ?-sympathomimetics, unlike dopamine, are of little therapeutic use; they are also arrhythmogenic and the sensitivity of the ?-receptor system declines during continuous stimulation. Treatment Principles in Chronic Heart Failure Myocardial insufficiency leads to a decrease in stroke volume and venous congestion with formation of edema.
Thus, reabsorption of NaCl and water is inhibited. Renal excretion of Ca2+ decreases, that of Mg2+ increases. Indications are hypertension, cardiac failure, and mobilization of edema.