Drug Name Differin

Type 2, cytotoxic reaction. Drugantibody (IgG) complexes adhere to the surface of blood cells, where either circulating drug molecules or complexes already formed in blood accumulate. These complexes mediate the activation of complement, a family of proteins that circulate in the blood in an inactive form, but can be activated in a cascadelike succession by an appropriate stimulus.
The active ingredients are absorbed through mucous membranes in the mouth and GIT and enter the blood stream. A fraction of pregastric drug absorption may bypass the digestive system and metabolism by the stomach acids and enzymes. In general, the tablets are physically robust and can be packaged in multidose containers16.

 

Pharmacological agents that act to dilate arterioles would thus be inappropriate because at rest they may divert blood from underperfused into healthy vascular regions on account of redundant arteriolar dilation. The resulting “steal effect” could provoke an anginal attack. (3)
When the drug is applied to the oral mucosa (buccal, sublingual route), plasma levels rise faster than with conventional oral administration because the drug preparation is deposited at its actual site of absorption and very high concentrations in saliva occur upon the dissolution of a single dose. Thus, uptake across the oral epithelium is accelerated.