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Anticipatory nausea and vomiting, resulting from inadequately controlled nausea and emesis in patients undergoing cytotoxic chemotherapy, can be attenuated by a benzodiazepine such as lorazepam.
Drugs that are subject to enterohepatic cycling are, therefore, excreted slowly. Pertinent examples include digitoxin and acidic nonsteroidal anti-inflammatory agents (p. 200). Conjugations (B) The most important of phase II conjugation reactions is glucuronidation.

 

The severity of these and other adverse reactions (e. g. , rage, violent hostility, hallucinations), and their increased frequency in the elderly, has led to curtailed or suspended use of triazolam in some countries (UK).
Type 2, cytotoxic reaction. Drugantibody (IgG) complexes adhere to the surface of blood cells, where either circulating drug molecules or complexes already formed in blood accumulate. These complexes mediate the activation of complement, a family of proteins that circulate in the blood in an inactive form, but can be activated in a cascadelike succession by an appropriate stimulus.

 

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