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The above forms of hypersensitivity must be distinguished from allergies involving the immune system (p. 72). Lack of selectivity (C). Despite appropriate dosing and normal sensitivity, undesired effects can occur because the drug does not specifically act on the targeted (diseased) tissue or organ.
The proteins are used as “viral enzymes” catalyzing viral multiplication (e. g. , DNA polymerase and thymidine kinase), as capsomers, or as coat components, or are incorporated into the host cell membrane. (5) Individual components are assembled into new virus particles (maturation). (6) Release of daughter viruses results in spread of virus inside and outside the organism.

 

The characteristic phasic time course of drug concentration in plasma represents the sum of the constituent processes of absorption, distribution, and elimination, which overlap in time.
The severity of these and other adverse reactions (e. g. , rage, violent hostility, hallucinations), and their increased frequency in the elderly, has led to curtailed or suspended use of triazolam in some countries (UK).

 

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