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Bronchial asthma: Increased sympathetic activity prevents bronchospasm in patients disposed to paroxysmal constriction of the bronchial tree (bronchial asthma, bronchitis in smokers). In this condition, ?2-receptor blockade will precipitate acute respiratory distress (B).
O2 demand falls because of the ensuing decrease in the two variables that determine systolic wall tension (afterload): ventricular filling volume and aortic blood pressure. Calcium antagonists (B) decrease O2 demand by lowering aortic pressure, one of the components contributing to afterload.

 

Furosemide or frusemide is a loop diuretic used in the treatment of congestive heart failure and edema. It is most commonly marketed by Sanofi-Aventis under the brand name Lasix. It has also been used to prevent Thoroughbred and Standardbred race horses from bleeding through the nose during races.
An altered position of aromatic hydroxyl groups (e. g. , in orciprenaline, fenoterol, or terbutaline) or their substitution (e. g. , salbutamol) protects against inactivation by COMT.

 

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