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High cAMP levels would stabilize the platelet in its inactive state. Formally, the two messenger substances, Ca2+ and cAMP, can be considered functional antagonists. Platelet aggregation can be inhibited by acetylsalicylic acid (ASA), which blocks thromboxane synthase, or by recombinant hirudin (originally harvested from leech salivary gland), which binds and inactivates thrombin.
A detectable immune response, the allergic reaction, occurs. This can be of severe intensity, even at a low dose of the antigen. Four types of reactions can be distinguished: Type 1, anaphylactic reaction. Drug-specific antibodies of the IgE type combine via their Fc moiety with receptors on the surface of mast cells. |
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