Drug Name Atarax

The therapeutic index of benzodiazepines, calculated with reference to the toxic dose producing respiratory depression, is greater than 100 and thus exceeds that of barbiturates and other sedative-hypnotics by more than tenfold. Benzodiazepine intoxication can be treated with a specific antidote (see below).
Two additional uses are cystinuria and rheumatoid arthritis. In the former, formation of cystine stones in the urinary tract is prevented because the drug can form a disulfide with cysteine that is readily soluble. In the latter, penicillamine can be used as a basal regimen.

 

As a consequence of local ischemia, extracellular concentrations of H+ and K+ rise in the affected region, leading to excitation of nociceptive nerve fibers. The resultant sensation of pain, typically experienced by the patient as annihilating, reinforces sympathetic activation.
Agents active against blood schizonts do not prevent the (symptom-free) hepatic infection, only the disease-causing infection of erythrocytes (“suppression therapy”). On return from an endemic malaria region, a 2 wk course of primaquine is adequate for eradication of the late hepatic stages (P. vivax and P. ovale).