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This leads to release from the kidneys of the hormone, renin, which enzymatically catalyzes the formation of angiotensin I. Angiotensin I is converted to angiotensin II by the action of angiotensin-converting enzyme (ACE). Angiotensin II stimulates release of aldosterone. The mineralocorticoid promotes renal reabsorption of NaCl and water and thus counteracts the effect of diuretics.
Drugs that are subject to enterohepatic cycling are, therefore, excreted slowly. Pertinent examples include digitoxin and acidic nonsteroidal anti-inflammatory agents (p. 200). Conjugations (B) The most important of phase II conjugation reactions is glucuronidation. |
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