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Various drugs can lower seizure threshold, notably certain neuroleptics, the tuberculostatic isoniazid, and ?-lactam antibiotics in high doses; they are, therefore, contraindicated in seizure disorders. Glutamate receptors comprise three subtypes, of which the NMDA subtype has the greatest therapeutic importance. (N-methyl-D-aspartate is a synthetic selective agonist. )
Nonsteroidal anti-inflammatory drugs, such as indomethacin and phenylbutazone, are also effective. In severe cases, glucocorticoids may be indicated. Effective prophylaxis of gout attacks requires urate blood levels to be lowered to less than 6 mg/100 mL. Diet. |
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