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Following its uptake into the body, the drug is distributed in the blood (1) and through it to the various tissues of the body. Distribution may be restricted to the extracellular space (plasma volume plus interstitial space) (2) or may also extend into the intracellular space (3).
However, immune suppression also entails weakened defenses against infectious pathogens and a long-term increase in the risk of neoplasms. A specific immune response begins with the binding of antigen by lymphocytes carrying specific receptors with the appropriate antigen-binding site.

 

Thus, reaction velocity reaches a plateau at blood ethanol concentrations of about 0. 02 %, and the amount of drug eliminated per unit of time remains constant at concentrations above this level. A. Drugs are taken up into and eliminated from the body by various routes.
When amphetamine-like substances are misused to enhance athletic performance (doping), there is a risk of dangerous physical overexertion. Because of the absence of a sense of fatigue, a drugged athlete may be able to mobilize ultimate energy reserves. In extreme situations, cardiovascular failure may result (B).

 

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