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Following its uptake into the body, the drug is distributed in the blood (1) and through it to the various tissues of the body. Distribution may be restricted to the extracellular space (plasma volume plus interstitial space) (2) or may also extend into the intracellular space (3).
Thus, reaction velocity reaches a plateau at blood ethanol concentrations of about 0. 02 %, and the amount of drug eliminated per unit of time remains constant at concentrations above this level. A. Drugs are taken up into and eliminated from the body by various routes. |
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