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On the contrary, spermatogenesis may be suppressed because of feedback inhibition of hypothalamohypophyseal gonadotropin secretion. Stimulation of spermatogenesis in gonadotropin (FSH, LH) deficiency can be achieved by injection of HMG and HCG. HMG or human menopausal gonadotropin is obtained from the urine of postmenopausal women and is rich in FSH activity.
With continued exposure, induction develops in a few days, resulting in an increase in reaction velocity, maximally 2–3fold, that disappears after removal of the inducing agent. Many drugs undergo chemical modification in the body (biotransformation).

 

If bacteria multiply faster than the body’s defenses can destroy them, infectious disease develops with inflammatory signs, e. g. , purulent wound infection or urinary tract infection. Appropriate treatment employs substances that injure bacteria and thereby prevent their further multiplication, without harming cells of the host organism (1).
In order to ensure a sufficiently fast build-up of drug concentration at the site of action, there must be a correspondingly large concentration gradient between drug depot in the connective tissue and the endoneural space.

 

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