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This leads to release from the kidneys of the hormone, renin, which enzymatically catalyzes the formation of angiotensin I. Angiotensin I is converted to angiotensin II by the action of angiotensin-converting enzyme (ACE). Angiotensin II stimulates release of aldosterone. The mineralocorticoid promotes renal reabsorption of NaCl and water and thus counteracts the effect of diuretics.
Although simple to perform, these binding assays pose the difficulty of correlating unequivocally the binding sites concerned with the pharmacological effect; this is particularly difficult when more than one population of binding sites is present. |
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