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Hepatic passage is circumvented when absorption occurs buccally or sublingually, because venous blood from the oral cavity drains directly into the superior vena cava. The same would apply to administration by inhalation. However, with this route, a local effect is usually intended; a systemic action is intended only in exceptional cases.
Morphine antagonists and partial agonists. The effects of opioids can be abolished by the antagonists naloxone or naltrexone (A), irrespective of the receptor type involved. Given by itself, neither has any effect in normal subjects; however, in opioid-dependent subjects, both precipitate acute withdrawal signs.

 

Purine (cell nuclei)-rich foods should be avoided, e. g. , organ meats. Milk, dairy products, and eggs are low in purines and are recommended. Coffee and tea are permitted since the methylxanthine caffeine does not enter purine metabolism. Uricostatics decrease urate production.
Before the introduction of the better tolerated acyclovir, vidarabine played a major part in the treatment of herpes simplex encephalitis. Among virustatic antimetabolites, acyclovir (A) has both specificity of the highest degree and optimal tolerability. because it undergoes bioactivation only in infected cells, where it preferentially inhibits viral DNA synthesis.

 

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