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It is poorly absorbed enterally and must be given parenterally to cause increased excretion of iron. Oral administration is indicated only if enteral absorption of iron is to be curtailed. Unwanted effects include allergic reactions.
Rapidly dividing malignant cells are preferentially injured. Damage to mitotic processes not only retards tumor growth but may also initiate apoptosis (programmed cell death). Tissues with a low mitotic rate are largely unaffected; likewise, most healthy tissues. This, however, also applies to malignant tumors consisting of slowly dividing differentiated cells.

 

Synthesis of prostaglandins (PG), prostacyclin, and thromboxane proceeds via intermediary cyclic endoperoxides. In the case of PG, a cyclopentane ring forms in the acyl chain.
Adverse effects. The frequent gastrointestinal complaints (epigastric pain, diarrhea, constipation) necessitate intake of iron preparations with or after meals, although absorption is higher from the empty stomach.

 

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