Drug Name Diflucan

According to the chemical structure of the side chain, phenothiazines and thioxanthenes can be subdivided into aliphatic (chlorpromazine, triflupromazine, p. 239 and piperazine congeners (trifluperazine, fluphenazine, flupentixol, p. 239). The antipsychotic effect is probably due to an antagonistic action at dopamine receptors.
The therapeutic effect may result in part from a reaction with aldehydes, whereby polymerization of collagen molecules into fibrils is inhibited. Unwanted effects are: cutaneous damage (diminished resistance to mechanical stress with a tendency to form blisters), nephrotoxicity, bone marrow depression, and taste disturbances.

 

In terms of their positive inotropic effect, ?-sympathomimetics, unlike dopamine, are of little therapeutic use; they are also arrhythmogenic and the sensitivity of the ?-receptor system declines during continuous stimulation. Treatment Principles in Chronic Heart Failure Myocardial insufficiency leads to a decrease in stroke volume and venous congestion with formation of edema.
The more rapid the administration, the shorter will be the time (tmax) required to reach the peak plasma level (cmax), the higher will be the cmax, and the earlier the plasma level will begin to fall again. The area under the plasma level time curve (AUC) is independent of the route of administration, provided the doses and bioavailability are the same (Dost’s law of corresponding areas).